First, did you check under system properties to see if your computer is 64bit or 32bit? This is dependent on your unit's build, rather than the OS. Second, did you download the 64bit version of Acid? I was given the choice between the two, 32bit being the default. I downloaded the 64bit, and it works perfectly. As you are running Win10Pro there may be permissions that have to be granted to run the 64bit under your OS. I wouldn't know about that, but I would check it out. Not much to go with, but that's where I would start. Like I said, I'm not having any issues with the program running under Win10 in 64bit mode. I hope you have or find a solution soon.